OTDOncology Treatment Discovery3083-49962981-8079Bio-Byword Scientific Publishing Pty. Ltd.10.26689/otd.v2i4.9338ArticleResearch Progress on the Antitumor Effects of Individual Herbs in the Zhuang Medicine Formula Weiduqinghttps://artdesignp.com/journal/OTD/2/4/10.26689/otd.v2i4.9338WuLaifeng,LuXiaonan,HuangAn,LiaoLingchen,YeLulu,ZhouQiaofeng,LuGuanfeng2024242024-12-31Gastric cancer is a prevalent malignant tumor that typically originates in the mucosal layer or near the gastric wall. If left untreated, it may spread to other organs, posing a severe threat to life. Currently, the primary treatment methods for gastric cancer are Western medical approaches, including surgical intervention, radiotherapy, chemotherapy, and biological targeted therapy. While these methods are highly targeted, they often come with significant adverse effects. Traditional compound formulas, with their multi-target and holistic regulatory advantages, can serve as primary or supplementary treatments for gastric cancer. They are also effective in mitigating side effects and are gaining increasing attention. In recent years, the research team has discovered that the Zhuang medicine formula Weiduqing demonstrates definitive efficacy in inhibiting gastric cancer tumors, with fewer toxic and side effects. This makes it a promising anti-cancer remedy with significant development potential. This article reviews the anti-tumor active components of individual herbs in the Weiduqing formula, providing a reference for its clinical promotion and further research.

Zou W, Li Z, 2014, Progress of Research on Incidence and Mortality of Gastric Cancer in China. Chinese Journal of Practical Internal Medicine, 34(04): 408–415.

Chen Q, Huang A, Liang D, et al., 2022, Effectiveness of Zhuang Medicine Prescription of Gastric Toxin Clearing in the Treatment of Yang Evidence Type Carcass Yin (Chronic Gastro-Sinusitis). Chinese Journal of Ethnic Medicine, 28(09): 1–4 + 23.

Luo Y, 2022, Effects of Zhuang Medical Prescription Gastric Toxicity Clear on the Expression of PTGS2/IL6/ICAM1 Factors in Nude Mice of Gastric Cancer Model, dissertation, Guangxi University of Traditional Chinese Medicine.

Hu Z, Tang M, Zhang Q, et al., 2018, Progress in the Study of Chemical Composition and Pharmacological Effects of Zaibiying. Journal of Changchun Normal University, 37(04): 69–74.

Zhao L, 2013, Response Surface Method for the Efficient Extraction of Three Herbs and Their Extracts, dissertation, Hebei University.

Xu R, 2009, Study on the Chemical Composition and Preliminary Screening of Anti-Tumor Active Ingredients of Ziabiying, dissertation, Guangzhou University of Traditional Chinese Medicine.

Nan M, He Y, Si X, et al., 2019, Synthesis and Antitumor Activity Analysis of the Derivatives of Zaobianolic Acid. Chinese Journal of Experimental Formulas, 25(11): 139–144.

Ren L, 2021, Inhibition of Gastric Cancer Growth by Berberine, an Active Ingredient of Rhizoma coptidis, through IL-6/JAK2/STAT3 Signaling Pathway and its Mechanism, dissertation, Southwest University.

Tian H, Fu S-W, Wang H, 2021, Effects of Berberine Hydrochloride on Proliferation, Apoptosis, Autophagy and MAPK Pathway of Gastric Cancer SGC-7901 Cells. Journal of Modern Integrative Medicine, 30(27): 2981–2986.

Wang H, Li Y, Wang Q, 2007, Progress of Antitumor Effects of Rhizoma Coptidis. Chinese Patent Medicine, 2007(10): 1500–1502.

Wu J, Li H, To S, et al., 2009, Experimental Study on the Induction of Apoptosis in Human Gastric Cancer SGC-7901 Cells by Aqueous Extract of Rhizoma Dioscoreae. Shizhen Guojian, 20(10): 2509–2511.

Liu S, Wei X, Bai M, 2010, Inhibitory Effect of Baiying Steroidal Saponins on Tumor Cell Proliferation In Vitro. Jiangxi Traditional Chinese Medicine, 41(01): 71–73.

Dong ZP, 2019, Experimental Study on Clinical Efficacy Observation and Action Mechanism of Baihe Fang in Treating Middle and Advanced Gastric Cancer, dissertation, Shanghai University of Traditional Chinese Medicine.

Zhang N, 2014, Research on the Law of Medication and Typical Cases of Professor Qi Yuanfu’s Treatment of Gastrointestinal Tumors, dissertation, Shandong University of Traditional Chinese Medicine.

Hu F, 2011, Summary of Professor Yu Rencun’s Academic Thoughts and Clinical Experience and Clinical Observation of Yiqi, Blood and Toxin Relieving Formula Combined with Chemotherapy in the Treatment of Advanced Gastric Cancer, dissertation, Beijing University of Traditional Chinese Medicine.

Quan X, 2011, Therapeutic Effects of Cynodon dactyliflorus and its Effective Fractions on Cancer. Journal of Chinese Medicine, 26(10): 1155–1157.

Liu X, Wu J, Zhang D, et al., 2018, Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative medicine, 2018: 7802639.

Wang Q, Gao X, Zhang X, 2015, Effects of Total Flavonoids of Cnidium albidum on Proliferation and Apoptosis of BGC-823 Gastric Cancer Cells. Journal of Modern Integrative Chinese and Western Medicine, 24(21): 2289–2292.

Su Y, Xia A, Su Z, et al., 2014, Study on the Apoptosis-Inducing Effect of Polysaccharides from Cynoglossus albus in Human Gastric Cancer Cells. Journal of Pharmacy of the People’s Liberation Army, 30(06): 493–496.

Jing Y, Kang M, Liu J, et al., 2015, Study on Apoptosis of Nasopharyngeal Carcinoma Cells Induced by Polysaccharides from Cynomolgus albus and its Mechanism. Journal of Clinical Otolaryngology Head and Neck Surgery, 29(07): 641–644.

Mao Y, 2015, Research on the Mechanism of Action of Polysaccharides of C. alba on Non-Small Cell Lung Cancer A549 Cells, dissertation, Hunan Agricultural University.

Zhang Y, Liu H, Song Y, et al., 2021, Effects of Polysaccharide Extracts of Hedyotis diffusa on Endoplasmic Reticulum Autophagy in Laryngeal Cancer Hep-2 Cells. Chinese Journal of Applied Physiology, 37(06): 660–664.

Liu W, 2021, Effects of Down-Regulation of miR-21-5p/PAG1 by Polysaccharides from Cynoglossum albidum on the Proliferation, Apoptosis, Migration and Invasion of Skin Squamous Carcinoma Cells. Chinese Journal of Gerontology, 41(24): 5672–5677.

Wu C, Xiong M, Tang X, et al., 2022, Exploration of the Idea of Treating Common Tumors with the Pair of Medicines of Bai Hua Snake Tongue Herb and Semen Ziziphiroxylon. China Traditional Chinese Medicine Modern Distance Education, 20(12): 199–202.

Wu X, Cui S, Wang Y, et al., 2018, Progress in the Study of Anti-Tumor Action Mechanism of the Active Components of Chinese Medicinal Herb Hemerocallis sinensis. Chinese Journal of Traditional Chinese Medicine, 33(04): 1459–1462.

Chen A, Zhu Z, Chen D, 2013, Effects of Hemicarpine Polysaccharide on the Expression of P21 and VEGF in a Mouse Gastric Cancer Model. China Pharmacoeconomics, 2013(06): 296–297.

Zhang Y, Zhang K, Zhao Q, et al., 2012, Inhibition of Infiltration and Metastasis of Gastric Cancer SGC-7901 Cells and its Mechanism. Shizhen Guomian Guomian, 23(11): 2692–2694.

Zhang F, Wu Z, Xu N, et al., 2022, Study on the Role and Mechanism of Total Flavonoids from Rhizoma Pinelliae in Modulating the Effect of MIIP on the Proliferation, Apoptosis and Sensitivity to Radiotherapy in Human Gastric Adenocarcinoma Cells AGS. Drug Evaluation Research, 45(04): 686–692.

Wei L, Fang G, 2019, Study on the Cellular Molecular Regulation Mechanism of Antitumor of Curcuma longa Active Ingredients. Journal of Guangxi University of Traditional Chinese Medicine, 22(03): 71–73.

Xu L, Liu L, Wang Y, et al., 2010, Experimental Study of Curcumol-Induced Apoptosis and Increased Intracellular Reactive Oxygen Species in Human Gastric Cancer BGC-823 Cells. Modern Oncology Medicine, 18(10): 1892–1895.

Zhang H, Zhang L, Jiang H, et al., 2015, Effect of Curcumol on Apoptosis and Expression of AIF and Endo G in Gastric Cancer SGC7901 cells. Journal of Oncology, 21(09): 703–707.

Zhou G, Deng S, Ban J, et al., 2023, Effect and Mechanism of Curcumol on Proliferation and Apoptosis of Gastric Cancer AGS Cell. Global Traditional Chinese Medicine, 16(07): 1301–1308.

Wang D, Li Y, Zhao Q, et al., 2015, Clinical Significance of Curcuma Oil Injection in Perioperative Application of Gastric Cancer Patients. Journal of Oncology, 21(05): 378–381.

Tang Y, 2004, Research on the Effect and Mechanism of Curcumol on Hepatocellular Carcinoma and Colon Cancer, dissertation, Third Military Medical University.

Liu J, Wang J, Jiang X, et al., 2012, Induction of Apoptosis in Nasopharyngeal Carcinoma CNE-2 Cells by Curcumol and its Anti-Tumor Mechanism. Shizhen Guomian Guomian, 23(06): 1339–1341.

Liu Z, Han F, Wu X, et al., 2010, Research Overview of Antitumor and Treatment of Ovarian Cancer by Curcuma longa Oil. Modern Journal of Integrative Medicine, 19(17): 2209–2210.

Lin H, Li X, 2008, Study on the Apoptosis-Inducing Effect of Curcumol on Leukemia L1210 Cells. China Pharmacy, 2008(30): 2328–2329.

Wan L, Qian X, Liu B, 2012, Progress of Research on the Chemical Composition of Alkaloids of Yanhusuo and Their Antitumor Effects. Modern Oncology Medicine, 20(05): 1042–1044.

Zhang G, Xie L, Yu L, et al., 2009, In Vitro Proliferation Inhibition of Six Human Gastric Cancer Cell Lines by Total Alkaloids of Yanhusuo. Chinese Journal of Integrative Medicine and Digestion, 17(02): 81–85.

Wan L, 2012, Experimental Study on the In Vivo Anti-Angiogenic and VEGF-Regulatory Effects of Fenugreek Alcohol Extract and Fenugreek Alkaloids, dissertation, Nanjing University of Traditional Chinese Medicine.

Sang X, Zhang L, Liu L, et al., 2009, Extraction of Alkaloids from Yanhuisuo and its Anti-Hepatic Tumor Activity. Journal of Zhejiang University of Technology, 26(05): 754–756.

Gao LJ, Shi MJ, He K, et al., 1994, Yanhusuo Extract Inhibits Metastasis of Breast Cancer Cells by Modulating Mitogen-Activated Protein Kinase Signaling Pathways. Oncology Reports, 20(4).

Shi W, Hao J, Shi X, 2020, In Vitro Study on the Inhibition of Gastric Cancer Progression by Total Saponins of Panax ginseng. Chinese Journal of Immunology, 36(03): 349–354.

Cai D, Lin L, Pan HF, et al., 2019, Protective Effects of Total Saponins of Panax Ginseng Activating JNK Signaling Pathway on Gastric Mucosal Tissues of Rats with Gastric Precancerous Lesions. Chinese Journal of Traditional Chinese Medicine, 34(12): 5877–5880.

Gao X, Zhang Y, Zhang Z, et al., 2019, Effects of Total Saponins of Panax ginseng on Proliferation, Invasion and Apoptosis of Human Gastric Cancer SGC-7901 Cells. Northwest Journal of Pharmacy, 34(02): 245–250.

Wu Z, Peng Y, Li Y, 2012, Effects of Total Saponins of Panax ginseng on Proliferation and Apoptosis of Human Gastric Cancer Cell Line MKN-28. Oncology Pharmacology, 2(05): 351–355 + 394.

Liang L, 2007, Prevention and Treatment of Tumors by Panax ginseng Diet. Chinese Folk Therapy, 2007(06): 61–62.

Lu HM, Sun WX, Huo CX, et al., 2020, Exploration of the Effects of Total Saponins of Panax ginseng on 4T1 Breast Cancer Tumor Model in Homozygous Mice Based on MEKK1/SEK1/JNK1/AP-1 Pathway. Chinese Journal of Experimental Formulas, 26(24): 75–81.

Yao L, Wu L, Wang W, et al., 2020, Panax Notoginseng Saponins Promote Cell Death and Chemosensitivity in Pancreatic Cancer through the Apoptosis and Autophagy Pathways. Anti-Cancer Agents in Medicinal Chemistry, 21(13): 1680–1688.

Zhang J, Zhou B, Jin S, et al., 2020, Mechanism of Action of Panax notoginoside against Lung Cancer in Mice Based on Response to CTSB Gene. BMC Complementary Medicine and Therapies, 20(1): 367.

Wang Z, Chai K, Chen J, 2017, Study on the Medication pattern of Chai Kequn for Gastric Cancer Based on Data Mining. Journal of Jiangxi University of Traditional Chinese Medicine, 29(01): 38–41.

Wei Y, Yin L, Zhang J, et al., 2022, Heterophyllin B Inhibits the Malignant Phenotypes of Gastric Cancer Cells via CXCR4. Human cell, 36(2): 676–688.

Xue W, Sun R, Hao Z, et al., 2023, Heterophyllin B Ameliorates Gastric Cancer Tumor Growth through Activating ER Stress. Tissue and Cell, 83: 102129.

Tantai JC, Zhang Y, Zhao H, 2016, Heterophyllin B Inhibits the Adhesion and Invasion of ECA-109 Human Esophageal Carcinoma Cells by Targeting PI3K/AKT/β-catenin Signaling. Molecular Medicine Reports, 13(2): 1097–1104.

Sun H, Shi K, Qi K, et al., 2020, Pseudostellaria heterophylla Extract Polysaccharide H-1-2 Suppresses Pancreatic Cancer by Inhibiting Hypoxia-Induced AG2. Molecular Therapy - Oncolytics, 17: 61–69.

Ye L, Deng Y, Ma C, et al., 2023, Progress of Antitumor Activity of Glycyrrhiza glabra. Journal of Shenyang Pharmaceutical University, 40(05): 655–662.

Jia HY, Lin F, Wang LM, et al., 2016, Inhibition of Proliferation and Induction of Apoptosis by Glycyrrhizic Acid on Human Gastric Cancer HGC-27. Heilongjiang Medical Science, 39(02): 88–90 + 92.

Yao J, Chi Y, Gao F, 2016, Effect and Mechanism of Glycyrrhizic Acid on the Proliferation of Human Gastric Cancer SGC7901 Cells. Journal of Xinxiang Medical College, 33(07): 577–580.

Niu Q, Liu F, Wang A, et al., 2015, Isoglycyrrhizin Induces Apoptosis in Human Gastric Cancer SGC7901 Cells through PI3K/Akt Pathway. World Chinese Journal of Digestion, 23(33): 5342–5347.

Zhang L, Ge Y, Lin Y, et al., 2010, Experimental Study on the In Vivo Anti-Gastric Cancer Effects of Licorice Flavonoids. Journal of Tongji University (Medical Edition), 31(06): 19–22 + 27.

Zhang L, Chen H, Wang M, et al., 2018, Effects of Glabridin Combined with 5-Fluorouracil on the Proliferation and Apoptosis of Gastric Cancer Cells. Oncology Letters, 15(5): 7037–7045.

Ma L, Zhao X, Ji Y, et al., 2008, Clinical Observation of Compound Glycyrrhizin in Gastrointestinal Tumor Chemotherapy to Improve Toxic Side Effects. Journal of Practical Liver Diseases, 2008(01): 38–39.

Chen X, Liu X, Li J, et al., 2022, Screening of Anti-Gastric Adenocarcinoma Flavonoids Targeting Estrogen Receptor Alpha. Chinese Drugs and Clinics, 22(05): 389–392.

Wang R, Liu Y, Chen J, et al., 2019, Antitumor Mechanism of Glycyrrhizic Acid and Glycyrrhizinic Acid and its Research Progress as a Drug Delivery Carrier. Chinese Herbal Medicine, 50(23): 5876–5886.

Yang Y, Xiao S, 2010, Progress of Research on the Influence of Formula Compounding on the Chemical Composition of Compound Formula. World Science and Technology (Modernisation of Traditional Chinese Medicine), 12(05): 699–707.