OTDOncology Treatment Discovery3083-49962981-8079Bio-Byword Scientific Publishing Pty. Ltd.10.26689/otd.v4i1.14270ArticleResearch Progress of Mir143 in Tumors and Its Guiding Significance in Lung Cancer Researchhttps://artdesignp.com/journal/OTD/4/1/10.26689/otd.v4i1.14270TongChengbi,QiJi,ZhuYaxing,YuYang,JiaTianhong2026412026-03-18MicroRNA-143 (miR-143) is a non-coding RNA molecule that plays a critical regulatory role in various biological processes, including cell proliferation, differentiation, and apoptosis. This review summarizes the structural characteristics of miR-143 and its expression patterns in different tumor types, with a particular focus on cervical cancer, colon cancer, and lung cancer. In most malignancies, miR-143 is downregulated and functions as a tumor suppressor by targeting oncogenes and modulating key signaling pathways. However, emerging evidence suggests that miR-143 may exhibit dual roles depending on the tumor context, as seen in certain lung cancer studies where its elevated expression correlates with poor prognosis. The interaction between miR-143 and long non-coding RNAs (lncRNAs) further expands its regulatory network and highlights its potential as a diagnostic biomarker and therapeutic target. A deeper understanding of miR-143’s multifaceted functions may offer new insights into tumor biology and treatment strategies.

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