PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v10i2.14299ArticleResearch Progress of Glucuronyl C5-Epimerase in Cancers: A Reviewhttps://artdesignp.com/journal/PAR/10/2/10.26689/par.v10i2.14299SuZixuan,HuWei20261022026-04-14Glucuronyl C5-epimerase (GLCE) is a key enzyme in heparan sulfate biosynthesis. Mice with a whole-genome knockout of GLCE exhibit embryonic lethality, highlighting its essential roles in growth and development and its involvement in processes such as obesity, neurogenesis, and immune regulation. Interestingly, GLCE exerts similar or even opposite effects in different cancers. The functional complexity of GLCE in cancers positions it as a promising biomarker and therapeutic target. However, current understanding of the roles and underlying mechanisms of GLCE in various cancers remains limited. This article reviews and discusses the functions and molecular mechanisms of GLCE in different cancers.

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