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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Proceedings of Anticancer Research</journal-title></journal-title-group><issn>2208-3545</issn><eissn>2208-3553</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/par.v10i3.14680</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>The Mechanisms and Research Progress of Chinese Medicine Monomers in Reversing Chemotherapy Resistance in Ovarian Cancer</title><url>https://artdesignp.com/journal/PAR/10/3/10.26689/par.v10i3.14680</url><author>JiXiaosui,ZhengXiaojiao,DingHuiqing</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>10</volume><issue>3</issue><history><date date-type="pub"><published-time>2026-05-31</published-time></date></history><abstract>The development of chemotherapy resistance is a critical factor leading to treatment failure and high mortality in ovarian cancer. Among current research directions, Chinese medicine monomers (CMMs) have shown great potential in reversing chemotherapy resistance due to their multi‑targeting properties and low toxicity. This review summarizes the research progress of various Chinese medicine monomers in reversing chemotherapy resistance in ovarian cancer, including polyphenols (such as quercetin, curcumin, epigallocatechin‑3‑gallate, resveratrol, kaempferol, myricetin, and ellagic acid), alkaloids (such as berberine, piperine, sanguinarine, and capsaicin), terpenoids (such as toosendanin and triptolide), and phenylpropanoids (such as myristicin and apiole). These monomers primarily exert their effects by regulating key signaling pathways (including PI3K/AKT/mTOR, p53, and NF-κB) and by interfering with critical processes such as drug efflux, DNA damage repair, apoptosis, and autophagy, thereby enhancing the sensitivity of ovarian cancer cells to chemotherapeutic agents like cisplatin. Furthermore, this review discusses the advantages of combination strategies involving Chinese medicine monomers, as well as the current challenges.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Bray F, Laversanne M, Sung H, et al., 2024, Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 74(3): 229–263.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Gonzalez-Martin A, Harter P, Leary A, et al., 2023, Newly Diagnosed and Relapsed Epithelial Ovarian Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up. Ann Oncol, 34(10): 833–848.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Havasi A, Cainap SS, Havasi AT, et al., 2023, Ovarian Cancer-Insights into Platinum Resistance and Overcoming It. Medicina (Kaunas), 59(3): 544.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Nag S, Aggarwal S, Rauthan A, et al., 2022, Maintenance Therapy for Newly Diagnosed Epithelial Ovarian Cancer-A Review. J Ovarian Res, 15(1): 88.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Yang L, Zhao H, Yin X, et al., 2020, Exploring Cisplatin Resistance in Ovarian Cancer Through Integrated Bioinformatics Approach and Overcoming Chemoresistance with Sanguinarine. Am J Transl Res, 12(3): 923–939.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Miao K, Liu W, Xu J, et al., 2023, Harnessing the Power of Traditional Chinese Medicine Monomers and Compound Prescriptions to Boost Cancer Immunotherapy. Front Immunol, 14: 1277243.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Wang Y, Xie L, Liu F, et al., 2024, Research Progress on Traditional Chinese Medicine-Induced Apoptosis Signaling Pathways in Ovarian Cancer Cells. J Ethnopharmacol, 319(Pt 2): 117299.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Zhang X, Wei X, Shi L, et al., 2025, The Latest Research Progress: Active Components of Traditional Chinese Medicine as Promising Candidates for Ovarian Cancer Therapy. J Ethnopharmacol, 337(Pt 1): 118811.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Miao L, Liu Y, Ali NM, et al., 2023, Bufalin Serves as a Pharmaceutic That Mitigates Drug Resistance. Drug Metab Rev, 55(3): 195–204.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Muttiah B, Abdullah NAH, 2025, Natural Compounds in Ovarian Cancer: Mechanistic Insights and Therapeutic Potential. Front Pharmacol, 16: 1687805.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Harrath AH, Jalouli M, Al-Zharani M, et al., 2026, Recent Update Targeting Autophagy-Apoptosis Crosstalk Using Bioactive Natural Products for Ovarian Cancer Treatment. Biomedicines, 14(1): 212.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Silva-Pinto PA, de Pontes JTC, Aguilar-Moron B, et al., 2025, Phytochemical Insights into Flavonoids in Cancer: Mechanisms, Therapeutic Potential, and the Case of Quercetin. Heliyon, 11(4): e42682.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Li XR, Qi L, Zhang XW, et al., 2025, Quercetin and Nano-Derivatives: Potential and Challenges in Cancer Therapy. Int J Nanomedicine, 20: 6701–6720.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Maciejczyk A, Surowiak P, 2013, Quercetin Inhibits Proliferation and Increases Sensitivity of Ovarian Cancer Cells to Cisplatin and Paclitaxel. Ginekol Pol, 84(7): 590–595.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Wang S, Zhao Z, Yu L, et al., 2025, Identification of Quercetin as a Natural MMP1 Inhibitor for Overcoming Cisplatin Resistance in Epithelial Ovarian Cancer. J Cancer, 16(8): 2578–2594.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Shamsi M, Babaahmadi-Rezaei H, Khedri A, et al., 2025, A Novel Approach to Overcome Cisplatin Resistance in Ovarian Cancer: Revealing the Synergistic Potential of Quercetin-Loaded Solid Lipid Nanoparticles. Iran Biomed J, 29(1 &amp; 2): 20–35.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Nabavi SF, Daglia M, Moghaddam AH, et al., 2014, Curcumin and Liver Disease: From Chemistry to Medicine. Compr Rev Food Sci Food Saf, 13(1): 62–77.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Kalinina EV, Hasan AAS, Tatarskiy VV, et al., 2022, Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin. Bull Exp Biol Med, 173(3): 371–375.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Ulker EB, Aktas EC, Seyhan MF, et al., 2024, Effects of Curcumin and Its Analogue Desmethoxycurcumin on miR-133b and Its Target Gene GSTP-1 in Cisplatin-Resistant Ovarian Cancer Cells. Anticancer Res, 44(12): 5351–5359.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Zhang J, Liu J, Xu X, et al., 2017, Curcumin Suppresses Cisplatin Resistance Development Partly via Modulating Extracellular Vesicle-Mediated Transfer of MEG3 and miR-214 in Ovarian Cancer. Cancer Chemother Pharmacol, 79(3): 479–487.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>Musial C, Kuban-Jankowska A, Gorska-Ponikowska M, 2020, Beneficial Properties of Green Tea Catechins. Int J Mol Sci, 21(5): 1744.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Ohishi T, Goto S, Monira P, et al., 2016, Anti-Inflammatory Action of Green Tea. Antiinflamm Antiallergy Agents Med Chem, 15(2): 74–90.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>Ahmad RS, Butt MS, Sultan MT, et al., 2015, Preventive Role of Green Tea Catechins from Obesity and Related Disorders Especially Hypercholesterolemia and Hyperglycemia. J Transl Med, 13: 79.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Kaihatsu K, Yamabe M, Ebara Y, 2018, Antiviral Mechanism of Action of Epigallocatechin-3-O-Gallate and Its Fatty Acid Esters. Molecules, 23(10): 2475.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Ozduran G, Becer E, Vatansever HS, 2023, The Role and Mechanisms of Action of Catechins in Neurodegenerative Diseases. J Am Nutr Assoc, 42(1): 67–74.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Eshraghi R, Bahrami A, Iravanlou FT, et al., 2025, Cardioprotective and Anti-Hypertensive Effects of Epigallocatechin Gallate: Novel Insights Into Biological Evidence. J Clin Hypertens (Greenwich), 27(6): e70036.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B27" content-type="article"><label>27</label><element-citation publication-type="journal"><p>Farhan M, 2022, Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer. Int J Mol Sci, 23(18): 10713.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B28" content-type="article"><label>28</label><element-citation publication-type="journal"><p>Xiao S, Jia H, Guo Y, et al., 2025, Chemoprophylactic Effects of Epigallocatechin Gallate in Female Reproductive Cancers - A Review. J Diet Suppl, 22(4): 487–510.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B29" content-type="article"><label>29</label><element-citation publication-type="journal"><p>Li X, Hou Y, Han G, et al., 2024, S100A4/NF-kappaB Axis Mediates the Anticancer Effect of Epigallocatechin-3-Gallate in Platinum-Resistant Ovarian Cancer. iScience, 27(2): 108885.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B30" content-type="article"><label>30</label><element-citation publication-type="journal"><p>Wang X, Jiang P, Wang P, et al., 2015, EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. PLoS One, 10(4): e0125402.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B31" content-type="article"><label>31</label><element-citation publication-type="journal"><p>Chan MM, Soprano KJ, Weinstein K, et al., 2006, Epigallocatechin-3-Gallate Delivers Hydrogen Peroxide to Induce Death of Ovarian Cancer Cells and Enhances Their Cisplatin Susceptibility. J Cell Physiol, 207(2): 389–396.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B32" content-type="article"><label>32</label><element-citation publication-type="journal"><p>Malaguarnera L, 2019, Influence of Resveratrol on the Immune Response. Nutrients, 11(5): 946.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B33" content-type="article"><label>33</label><element-citation publication-type="journal"><p>Aggarwal BB, Bhardwaj A, Aggarwal RS, et al., 2004, Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Res, 24(5A): 2783–2840.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B34" content-type="article"><label>34</label><element-citation publication-type="journal"><p>Jeong KJ, Cho KH, Panupinthu N, et al., 2013, EGFR Mediates LPA-Induced Proteolytic Enzyme Expression and Ovarian Cancer Invasion: Inhibition by Resveratrol. Mol Oncol, 7(1): 121–129.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B35" content-type="article"><label>35</label><element-citation publication-type="journal"><p>Ferraresi A, Esposito A, Girone C, et al., 2021, Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy. Cells, 10(11): 3213.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B36" content-type="article"><label>36</label><element-citation publication-type="journal"><p>Muhanmode Y, Wen MK, Maitinuri A, et al., 2022, Curcumin and Resveratrol Inhibit Chemoresistance in Cisplatin-Resistant Epithelial Ovarian Cancer Cells via Targeting P13K Pathway. Hum Exp Toxicol, 41: 9603271221095929.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B37" content-type="article"><label>37</label><element-citation publication-type="journal"><p>Baribeau S, Chaudhry P, Parent S, et al., 2014, Resveratrol Inhibits Cisplatin-Induced Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cell Lines. PLoS One, 9(1): e86987.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B38" content-type="article"><label>38</label><element-citation publication-type="journal"><p>Engelke LH, Hamacher A, Proksch P, et al., 2016, Ellagic Acid and Resveratrol Prevent the Development of Cisplatin Resistance in the Epithelial Ovarian Cancer Cell Line A2780. J Cancer, 7(4): 353–363.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B39" content-type="article"><label>39</label><element-citation publication-type="journal"><p>Ma X, Zhang X, Wang X, et al., 2023, The Role of Kaempferol in Gynaecological Malignancies: Progress and Perspectives. Front Pharmacol, 14: 1310416.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B40" content-type="article"><label>40</label><element-citation publication-type="journal"><p>de Morais EF, de Oliveira LQR, Farias Morais HG, et al., 2024, The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies. Cancers (Basel), 16(3): 585.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B41" content-type="article"><label>41</label><element-citation publication-type="journal"><p>Luo H, Daddysman MK, Rankin GO, et al., 2010, Kaempferol Enhances Cisplatin’s Effect on Ovarian Cancer Cells Through Promoting Apoptosis Caused by Down Regulation of c-Myc. Cancer Cell Int, 10: 16.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B42" content-type="article"><label>42</label><element-citation publication-type="journal"><p>El-Kott AF, Shati AA, Al-Kahtani MA, et al., 2020, Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B. Folia Biol (Praha), 66(1): 36–46.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B43" content-type="article"><label>43</label><element-citation publication-type="journal"><p>Song X, Tan L, Wang M, et al., 2021, Myricetin: A Review of the Most Recent Research. Biomed Pharmacother, 134: 111017.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B44" content-type="article"><label>44</label><element-citation publication-type="journal"><p>Taheri Y, Suleria HAR, Martins N, et al., 2020, Myricetin Bioactive Effects: Moving from Preclinical Evidence to Potential Clinical Applications. BMC Complement Med Ther, 20(1): 241.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B45" content-type="article"><label>45</label><element-citation publication-type="journal"><p>Gupta G, Siddiqui MA, Khan MM, et al., 2020, Current Pharmacological Trends on Myricetin. Drug Res (Stuttg), 70(10): 448–454.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B46" content-type="article"><label>46</label><element-citation publication-type="journal"><p>Chen L, Fan T, Wang M, et al., 2024, Myricetin, a Natural Inhibitor of CD147, Increases Sensitivity of Cisplatin in Ovarian Cancer. Expert Opin Ther Targets, 28(1–2): 83–95.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B47" content-type="article"><label>47</label><element-citation publication-type="journal"><p>Huang H, Chen AY, Ye X, et al., 2015, Myricetin Inhibits Proliferation of Cisplatin-Resistant Cancer Cells Through a p53-Dependent Apoptotic Pathway. Int J Oncol, 47(4): 1494–1502.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B48" content-type="article"><label>48</label><element-citation publication-type="journal"><p>Ceci C, Lacal PM, Tentori L, et al., 2018, Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid. Nutrients, 10(11): 1756.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B49" content-type="article"><label>49</label><element-citation publication-type="journal"><p>Liu H, Zeng Z, Wang S, et al., 2017, Main Components of Pomegranate, Ellagic Acid and Luteolin, Inhibit Metastasis of Ovarian Cancer by Down-Regulating MMP2 and MMP9. Cancer Biol Ther, 18(12): 990–999.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B50" content-type="article"><label>50</label><element-citation publication-type="journal"><p>Elsaid FG, Alshehri MA, Shati AA, et al., 2020, The Anti-Tumourigenic Effect of Ellagic Acid in SKOV-3 Ovarian Cancer Cells Entails Activation of Autophagy Mediated by Inhibiting Akt and Activating AMPK. Clin Exp Pharmacol Physiol, 47(9): 1611–1621.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B51" content-type="article"><label>51</label><element-citation publication-type="journal"><p>Mandal T, Shukla D, Pattanayak S, et al., 2024, Ellagic Acid Induces DNA Damage and Apoptosis in Cancer Stem-like Cells and Overcomes Cisplatin Resistance. ACS Omega, 9(50): 48988–49000.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B52" content-type="article"><label>52</label><element-citation publication-type="journal"><p>Ruan H, Zhan YY, Hou J, et al., 2017, Berberine Binds RXRalpha to Suppress Beta-Catenin Signaling in Colon Cancer Cells. Oncogene, 36(50): 6906–6918.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B53" content-type="article"><label>53</label><element-citation publication-type="journal"><p>Ortiz LM, Lombardi P, Tillhon M, et al., 2014, Berberine, an Epiphany Against Cancer. Molecules, 19(8): 12349–12367.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B54" content-type="article"><label>54</label><element-citation publication-type="journal"><p>Duda-Madej A, Viscardi S, Szewczyk W, et al., 2024, Natural Alkaloids in Cancer Therapy: Berberine, Sanguinarine and Chelerythrine Against Colorectal and Gastric Cancer. Int J Mol Sci, 25(15): 8375.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B55" content-type="article"><label>55</label><element-citation publication-type="journal"><p>Tamtaji Z, Sheikhsagha E, Behnam M, et al., 2025, Berberine and Lung Cancer: From Pure Form to Its Nanoformulations. Asia Pac J Clin Oncol, 21(5): 455–464.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B56" content-type="article"><label>56</label><element-citation publication-type="journal"><p>Chen H, Ye C, Wu C, et al., 2023, Berberine Inhibits High Fat Diet-Associated Colorectal Cancer Through Modulation of the Gut Microbiota-Mediated Lysophosphatidylcholine. Int J Biol Sci, 19(7): 2097–2113.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B57" content-type="article"><label>57</label><element-citation publication-type="journal"><p>Chakraborty S, Ghosh BN, 2025, Berberine and Its Impact on Breast Cancer: Unveiling Key Signalling Pathways. Mol Biol Rep, 52(1): 719.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B58" content-type="article"><label>58</label><element-citation publication-type="journal"><p>Marverti G, Ligabue A, Lombardi P, et al., 2013, Modulation of the Expression of Folate Cycle Enzymes and Polyamine Metabolism by Berberine in Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cells. Int J Oncol, 43(4): 1269–1280.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B59" content-type="article"><label>59</label><element-citation publication-type="journal"><p>Chen Q, Qin R, Fang Y, et al., 2015, Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway. Cell Physiol Biochem, 36(3): 956–965.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B60" content-type="article"><label>60</label><element-citation publication-type="journal"><p>Mitra S, Anand U, Jha NK, et al., 2021, Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives. Front Pharmacol, 12: 772418.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B61" content-type="article"><label>61</label><element-citation publication-type="journal"><p>Wiraswati HL, Ma’ruf IF, Sharifi-Rad J, et al., 2025, Piperine: An Emerging Biofactor with Anticancer Efficacy and Therapeutic Potential. Biofactors, 51(1): e2134.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B62" content-type="article"><label>62</label><element-citation publication-type="journal"><p>Wojtowicz K, Sterzynska K, Swierczewska M, et al., 2021, Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs. Int J Mol Sci, 22(8): 4243.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B63" content-type="article"><label>63</label><element-citation publication-type="journal"><p>Achkar IW, Mraiche F, Mohammad RM, et al., 2017, Anticancer Potential of Sanguinarine for Various Human Malignancies. Future Med Chem, 9(9): 933–950.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B64" content-type="article"><label>64</label><element-citation publication-type="journal"><p>Ullah A, Ullah N, Nawaz T, et al., 2023, Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment. Anticancer Agents Med Chem, 23(7): 765–778.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B65" content-type="article"><label>65</label><element-citation publication-type="journal"><p>Sarkhosh-Inanlou R, Molaparast M, Mohammadzadeh A, et al., 2020, Sanguinarine Enhances Cisplatin Sensitivity via Glutathione Depletion in Cisplatin-Resistant Ovarian Cancer (A2780) Cells. Chem Biol Drug Des, 95(2): 215–223.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B66" content-type="article"><label>66</label><element-citation publication-type="journal"><p>Zhang W, Zhang Y, Fan J, et al., 2024, Pharmacological Activity of Capsaicin: Mechanisms and Controversies (Review). Mol Med Rep, 29(3): 38.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B67" content-type="article"><label>67</label><element-citation publication-type="journal"><p>Brown KC, Sugrue AM, Conley KB, et al., 2024, Anti-Cancer Activity of Capsaicin and Its Analogs in Gynecological Cancers. Adv Cancer Res, 164: 241–281.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B68" content-type="article"><label>68</label><element-citation publication-type="journal"><p>Sailo BL, Garhwal A, Mishra A, et al., 2025, Potential of Capsaicin as a Combinatorial Agent to Overcome Chemoresistance and to Improve Outcomes of Cancer Therapy. Biochem Pharmacol, 236: 116828.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B69" content-type="article"><label>69</label><element-citation publication-type="journal"><p>Arzuman L, Beale P, Chan C, et al., 2014, Synergism from Combinations of Tris(benzimidazole) Monochloroplatinum(II) Chloride with Capsaicin, Quercetin, Curcumin and Cisplatin in Human Ovarian Cancer Cell Lines. Anticancer Res, 34(10): 5453–5464.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B70" content-type="article"><label>70</label><element-citation publication-type="journal"><p>Li S, Xiong Q, Shen Y, et al., 2024, Toosendanin: Upgrade of an Old Agent in Cancer Treatment. Chin J Nat Med, 22(10): 887–899.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B71" content-type="article"><label>71</label><element-citation publication-type="journal"><p>Hu M, Xu M, Chen Y, et al., 2023, Therapeutic Potential of Toosendanin: Novel Applications of an Old Ascaris Repellent as a Drug Candidate. Biomed Pharmacother, 167: 115541.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B72" content-type="article"><label>72</label><element-citation publication-type="journal"><p>Wang G, Li L, Li Y, et al., 2023, Toosendanin Reduces Cisplatin Resistance in Ovarian Cancer through Modulating the miR-195/ERK/beta-Catenin Pathway. Phytomedicine, 109: 154571.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B73" content-type="article"><label>73</label><element-citation publication-type="journal"><p>Liu Z, Ma L, Zhou GB, 2011, The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules, 16(6): 5283–5297.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B74" content-type="article"><label>74</label><element-citation publication-type="journal"><p>Song J, He GN, Dai L, 2023, A Comprehensive Review on Celastrol, Triptolide and Triptonide: Insights on Their Pharmacological Activity, Toxicity, Combination Therapy, New Dosage Form and Novel Drug Delivery Routes. Biomed Pharmacother, 162: 114705.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B75" content-type="article"><label>75</label><element-citation publication-type="journal"><p>Wang R, Ma X, Su S, et al., 2018, Triptolide Antagonized the Cisplatin Resistance in Human Ovarian Cancer Cell Line A2780/CP70 via hsa-mir-6751. Future Med Chem, 10(16): 1947–1955.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B76" content-type="article"><label>76</label><element-citation publication-type="journal"><p>Zhong Y, Le F, Cheng J, et al., 2026, Triptolide Inhibits JAK2/STAT3 Signaling and Induces Lethal Autophagy through ROS Generation in Cisplatin-Resistant SKOV3/DDP Ovarian Cancer Cells. Oncol Rep, 55(3): 43.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B77" content-type="article"><label>77</label><element-citation publication-type="journal"><p>Zhong YY, Chen HP, Tan BZ, et al., 2013, Triptolide Avoids Cisplatin Resistance and Induces Apoptosis via the Reactive Oxygen Species/Nuclear Factor-kappaB Pathway in SKOV3(PT) Platinum-Resistant Human Ovarian Cancer Cells. Oncol Lett, 6(4): 1084–1092.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B78" content-type="article"><label>78</label><element-citation publication-type="journal"><p>Seneme EF, Dos Santos DC, de Lima CA, et al., 2022, Effects of Myristicin in Association with Chemotherapies on the Reversal of the Multidrug Resistance (MDR) Mechanism in Cancer. Pharmaceuticals (Basel), 15(10): 1233.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B79" content-type="article"><label>79</label><element-citation publication-type="journal"><p>Bao H, Muge Q, 2021, Anticancer Effect of Myristicin on Hepatic Carcinoma and Related Molecular Mechanism. Pharm Biol, 59(1): 1126–1132.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B80" content-type="article"><label>80</label><element-citation publication-type="journal"><p>Song J, Xu X, He S, et al., 2023, Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ERK Signaling Pathway. Curr Mol Pharmacol, 16(7): 712–724.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B81" content-type="article"><label>81</label><element-citation publication-type="journal"><p>Sufina Nazar S, Ayyappan JP, 2024, Mechanistic Evaluation of Myristicin on Apoptosis and Cell Cycle Regulation in Breast Cancer Cells. J Biochem Mol Toxicol, 38(6): e23740.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B82" content-type="article"><label>82</label><element-citation publication-type="journal"><p>Seneme EF, Dos Santos DC, Silva EMR, et al., 2021, Pharmacological and Therapeutic Potential of Myristicin: A Literature Review. Molecules, 26(19): 5914.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B83" content-type="article"><label>83</label><element-citation publication-type="journal"><p>Wu KH, Lee WJ, Cheng TC, et al., 2019, Study of the Antitumor Mechanisms of Apiole Derivatives (AP-02) from Petroselinum crispum through Induction of G0/G1 Phase Cell Cycle Arrest in Human COLO 205 Cancer Cells. BMC Complement Altern Med, 19(1): 188.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B84" content-type="article"><label>84</label><element-citation publication-type="journal"><p>Misic D, Tadic V, Korzeniowska M, et al., 2020, Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity. Molecules, 25(14): 3163.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B85" content-type="article"><label>85</label><element-citation publication-type="journal"><p>Afonso de Lima C, de Souza Bueno IL, Nunes Siqueira, et al., 2020, Reversal of Ovarian Cancer Cell Lines Multidrug Resistance Phenotype by the Association of Apiole with Chemotherapies. Pharmaceuticals (Basel), 13(10): 327.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B86" content-type="article"><label>86</label><element-citation publication-type="journal"><p>Arzuman L, Beale P, Yu JQ, et al., 2015, Monofunctional Platinum-Containing Pyridine-Based Ligand Acts Synergistically in Combination with the Phytochemicals Curcumin and Quercetin in Human Ovarian Tumour Models. Anticancer Res, 35(5): 2783–2794.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B87" content-type="article"><label>87</label><element-citation publication-type="journal"><p>Koren Carmi Y, Mahmoud H, Khamaisi H, et al., 2020, Flavonoids Restore Platinum Drug Sensitivity to Ovarian Carcinoma Cells in a Phospho-ERK1/2-Dependent Fashion. Int J Mol Sci, 21(18): 653.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B88" content-type="article"><label>88</label><element-citation publication-type="journal"><p>Chen H, Landen CN, Li Y, et al., 2013, Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane. J Oncol, 2013: 872957.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B89" content-type="article"><label>89</label><element-citation publication-type="journal"><p>Yunos NM, Beale P, Yu JQ, et al., 2011, Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells. Anticancer Res, 31(4): 1131–1140.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B90" content-type="article"><label>90</label><element-citation publication-type="journal"><p>Cai YY, Lin WP, Li AP, et al., 2013, Combined Effects of Curcumin and Triptolide on an Ovarian Cancer Cell Line. Asian Pac J Cancer Prev, 14(7): 4267–4271.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B91" content-type="article"><label>91</label><element-citation publication-type="journal"><p>Nam JS, Sharma AR, Nguyen LT, et al., 2016, Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine. Molecules, 21(1): E108.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B92" content-type="article"><label>92</label><element-citation publication-type="journal"><p>Trofin AM, Scripcariu DV, Filipiuc SI, et al., 2025, From Nature to Nanomedicine: Enhancing the Antitumor Efficacy of Rhein, Curcumin, and Resveratrol. Medicina (Kaunas), 61(6): 981.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B93" content-type="article"><label>93</label><element-citation publication-type="journal"><p>Niedzwiecki A, Roomi MW, Kalinovsky T, et al., 2016, Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients, 8(9): 552.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B94" content-type="article"><label>94</label><element-citation publication-type="journal"><p>Cui Y, Zhou Q, Jin M, et al., 2024, Research Progress on Pharmacological Effects and Bioavailability of Berberine. Naunyn Schmiedebergs Arch Pharmacol, 397(11): 8485–8514.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B95" content-type="article"><label>95</label><element-citation publication-type="journal"><p>Quijia CR, Araujo VH, Chorilli M, 2021, Piperine: Chemical, Biological and Nanotechnological Applications. Acta Pharm, 71(2): 185–213.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B96" content-type="article"><label>96</label><element-citation publication-type="journal"><p>Atriya A, Majee C, Mazumder R, et al., 2023, Insight into the Various Approaches for the Enhancement of Bioavailability and Pharmacological Potency of Terpenoids: A Review. Curr Pharm Biotechnol, 24(10): 1228–1244.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B97" content-type="article"><label>97</label><element-citation publication-type="journal"><p>Le Roy J, Huss B, Creach A, et al., 2016, Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants. Front Plant Sci, 7: 735.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B98" content-type="article"><label>98</label><element-citation publication-type="journal"><p>Zeinali R, Zaeifi D, Zolfaghari-Moghaddam, et al., 2025, Current Advances in Nanocarriers for Cancer Therapy. Int J Nanomedicine, 20: 12217–12262.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B99" content-type="article"><label>99</label><element-citation publication-type="journal"><p>Din FU, Aman W, Ullah I, et al., 2017, Effective Use of Nanocarriers as Drug Delivery Systems for the Treatment of Selected Tumors. Int J Nanomedicine, 12: 7291–7309.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B100" content-type="article"><label>100</label><element-citation publication-type="journal"><p>Asiri A, Bokahri BT, Sadaf, et al., 2025, Curcumin, EGCG and Apigenin in Cervical Cancer: Mechanistic Insights and Therapeutic Potential. Front Pharmacol, 16: 1592395.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B101" content-type="article"><label>101</label><element-citation publication-type="journal"><p>Khan MM, Madni A, Tahir N, et al., 2020, Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles. Int J Nanomedicine, 15: 2207–2217.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B102" content-type="article"><label>102</label><element-citation publication-type="journal"><p>Koochaki R, Amini E, Zarehossini S, et al., 2024, Alkaloids in Cancer Therapy: Targeting the Tumor Microenvironment and Metastasis Signaling Pathways. Fitoterapia, 179: 106222.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B103" content-type="article"><label>103</label><element-citation publication-type="journal"><p>Islam MR, Rahman MM, Dhar PS, et al., 2023, The Role of Natural and Semi-Synthetic Compounds in Ovarian Cancer: Updates on Mechanisms of Action, Current Trends and Perspectives. Molecules, 28(5): 2070.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B104" content-type="article"><label>104</label><element-citation publication-type="journal"><p>Shi M, Zhang MJ, Yu Y, et al., 2023, Curcumin Derivative NL01 Induces Ferroptosis in Ovarian Cancer Cells via HCAR1/MCT1 Signaling. Cell Signal, 109: 110791.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
