PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v5i3.2108Articlehttps://artdesignp.com/journal/PAR/5/3/10.26689/par.v5i3.2108XueHanmei,RenXiaofang2021532021-05-31Objective: To observe the clinical effect of Jieyu decoction in treating generalized anxiety disorder with stagnation-heat in liver meridian type. Methods: There were 72 cases of generalized anxiety disorders outpatient and inpatient patients, and 36 in the control and treatment group. The control group was given oral Deanxit; the treatment group was given Jieyu decoction granules, and necessary psychological counseling was given to patients in both groups. Changes in traditional Chinese medicine syndrome scoring scale, Hamilton scale (HAMA), dynamic electrocardiogram heart rate variability and other indicators were recorded and compared between the two groups. Results: The total effective rate of the control group was 76.5%, and the total effective rate of the treatment group was 80.0%. The curative effect of the treatment group and the control group was significantly higher than that before treatment (P < 0.05), and there was no significant difference in the overall curative effect between the two groups (P > 0.05). The HAMA scale score of the two groups was significantly lower than that before treatment (P < 0.05), and there was no significant difference in the reduction rate of HAMA score between the two groups (P > 0.05). The traditional Chinese medicine syndrome scores of the two groups were significantly decreased compared with that before treatment (P < 0.05). The traditional Chinese medicine syndrome scores of the treatment group were significantly different from that of the control group after 8 weeks of treatment (P < 0.05). Two groups of heart rate variability in 24 h period of standard deviation between the average normal R - R (SDNN), 24 h per 5 min normal R - R period between the standard deviation (SDANN), root mean square of phase difference between adjacent R - R (RMSSD) and the number of cardiac 50 ms accounted for the percentage of the total number of cardiac (PNN50) than before treatment significantly increased (P < 0.05), 8 weeks after treatment the SDNN, SDANN than the control group no significant difference (P > 0.05), RMSSD,PNN50 significantly difference compared with control group (P < 0.05). Conclusion: Jieyu decoction has good efficacy and high safety in the treatment of generalized anxiety disorder of the type of liver meridian and heat stagnation, which is suitable for clinical promotion and application.