PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v6i1.2840ArticleImprovement of Clinical Symptoms and Gut Microbiome After Fecal Microbiota Transplantation: A Case Study of a 106-Year-Old Man with MODShttps://artdesignp.com/journal/PAR/6/1/10.26689/par.v6i1.2840FangJingyun,YinJiayu,LiuQinghong,YangXiangyi,HeXuesong,WangShengzhou,FanMin,AlnaggarMohammed,WangJingsu,DengZhaoqun,LiuYuanfei2022612022-01-19Fecal microbiota transplantation (FMT) has been used in a wide variety of diseases. Many researchers hypothesize that the dysbiosis of intestinal microbiota plays an important role in the development of gut-derived infections; thus, FMT is a potential therapeutic target against multiple organ dysfunction syndrome (MODS). A 106-year-old male patient was initially diagnosed with cerebral infarction and pulmonary infection. During the course of hospitalization, the patient developed MODS. The patient received a single nasogastric infusion of sterile-filtered, pathogen-free feces from a healthy donor. Fecal samples were collected every two days post-infusion to monitor changes in the microbiota composition in response to treatment. After FMT, MODS and severe diarrhea were alleviated; the patient’s fecal microbiome diversity resembled that of the healthy donor’s fecal microbiome; moreover, his clinical symptoms improved remarkably with the changes in fecal microbiome. Additionally, no observable side effects were noted during FMT treatment. These findings warrant further investigation of FMT as a putative new therapy for treating microbiota-related diseases, such as MODS.

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