<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Proceedings of Anticancer Research</journal-title></journal-title-group><issn>2208-3545</issn><eissn>2208-3553</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/par.v6i2.3731</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Anti-Inflammatory and Anti-Angiogenic Properties of VitD3 in Ovarian Cancer</title><url>https://artdesignp.com/journal/PAR/6/2/10.26689/par.v6i2.3731</url><author>SaghafiNafiseh,AbdollahiElham,KhajoueeMahsa</author><pub-date pub-type="publication-year"><year>2022</year></pub-date><volume>6</volume><issue>2</issue><history><date date-type="pub"><published-time>2022-03-10</published-time></date></history><abstract>Ovarian malignancies are the most complicated type among all gynecological cancers. Their etiology is yet unknown; however, they are a heterogeneous, rapidly growing, and very fatal group of cancers. Chronic inflammation and angiogenesis appear to have major contributions in the development and progression of ovarian malignancies. Angiogenesis and inflammation are involved in the pathogenesis of ovarian cancer. Vitamin D3 (VitD3) has shown to have anti-inflammatory and anti-angiogenic properties in different types of cancers. The anti-inflammatory and anti-angiogenesis effects of VitD3 on ovarian cancer are investigated in this review.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Coburn S, Bray F, Sherman M, et al., 2017, International Patterns and Trends in Ovarian Cancer Incidence, Overall and by Histologic Subtype. International Journal of Cancer, 140(11): 2451-2460.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Jayson GC, Kohn EC, Kitchener HC, et al., 2014, Ovarian Cancer. The Lancet, 384(9951): 1376-1388.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Soslow RA, 2008, Histologic Subtypes of Ovarian Carcinoma: An Overview. International Journal of Gynecological Pathology, 27(2): 161-74.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Maccio A, Madeddu C, 2012, Inflammation and Ovarian Cancer. Cytokine, 58(2): 133-147.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Shivappa N, Hebert JR, Rosato V, et al., 2016, Dietary Inflammatory Index and Ovarian Cancer Risk in a Large Italian Case-Control Study. Cancer Causes &amp; Control, 27(7): 897-906.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Heyden E, Wimalawansa S, 2018, Vitamin D: Effects on Human Reproduction, Pregnancy, and Fetal Well-Being. The Journal of Steroid Biochemistry and Molecular Biology, 180: 41-50.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Veldurthy V, Wei R, Oz L, et al., 2016, Vitamin D, Calcium Homeostasis and Aging. Bone Research, 4(1): 1-7.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Umar M, Sastry KS, Chouchane AI, 2018, Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. International Journal of Molecular Sciences, 19(6): 1618.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Eisman J, MacIntyre I, Martin T, et al., 1979, 1,25-Dihydroxyvitamin-D Receptor in Breast Cancer Cells. The Lancet, 314(8156-8157): 1335-1336.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Makishima M, Lu TT, Xie W, et al., 2002, Vitamin D Receptor as an Intestinal Bile Acid Sensor. Science, 296(5571): 1313-1316.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Nian D, Li Z, Sun J, et al., 2021, Effect of 1,25 (OH) 2D3 on Experimental Autoimmune Neuritis and Its Mechanism. Trends in Immunotherapy, 5(2.1): 42-50.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Abdollahi E, Rezaee SA, Saghafi N, et al., 2020, Evaluation of the Effects of 1,25 vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-Deficient Women with Unexplained Recurrent Pregnancy Loss. Current Molecular Pharmacology, 13(4): 306-317.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Li N, Saghafi N, Ghaneifar Z, et al., 2021, Evaluation of the Effects of 1,25VitD3 on Inflammatory Responses and IL-25 Expression. Frontiers in Genetics, 12: 779494.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Abdollahi E, Saghafi N, Rezaee SAR, et al., 2020, Evaluation of 1, 25 (OH) 2D3 Effects on FOXP3, ROR-?t, GITR, and CTLA-4 Gene Expression in PBMCs of Vitamin D-Deficient Women with Unexplained Recurrent Pregnancy Loss. Iranian Biomedical Journal, 24(5): 295.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Illescas-Montes R, Melguizo-Rodríguez L, Ruiz C, et al., 2019, Vitamin D and Autoimmune Diseases. Life Sciences, 233: 116744.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Deuster E, Jeschke U, Ye Y, et al., 2017, Vitamin D and VDR in Gynecological Cancers – A Systematic Review. International Journal of Molecular Sciences, 18(11): 2328.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Liu Y, Li C, Chen P, et al., 2013, Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis. PLoS One, 8(6): e66716.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Yin L, Grandi N, Raum E, et al., 2011, Meta-Analysis: Circulating Vitamin D and Ovarian Cancer Risk. Gynecologic Oncology, 121(2): 369-375.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Savant SS, Sriramkumar S, O’Hagan HM, 2018, The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer. Cancers, 10(8): 251.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Jia D, Nagaoka Y, Katsumata M, et al., 2018, Inflammation is a Key Contributor to Ovarian Cancer Cell Seeding. Scientific Reports, 8(1): 1-7.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>Pannunzio A, Coluccia M, 2018, Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. Pharmaceuticals, 11(4): 101.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Deng L, Feng D, Ling B, 2020, Cyclooxygenase-2 Promotes Ovarian Cancer Cell Migration and Cisplatin Resistance Via Regulating Epithelial Mesenchymal Transition. Journal of Zhejiang University-SCIENCE B, 21(4): 315-326.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>El-Sharkawy A, Malki A, 2020, Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications. Molecules, 25(14): 3219.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Thill M, Woeste A, Reichert K, et al., 2015, Vitamin D Inhibits Ovarian Cancer Cell Line Proliferation in Combination with Celecoxib and Suppresses Cyclooxygenase-2 Expression. Anticancer Research, 35(2): 1197-1203.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Kavandi L, Collier MA, Nguyen H, et al., 2012, Progesterone and Calcitriol Attenuate Inflammatory Cytokines CXCL1 and CXCL2 in Ovarian and Endometrial Cancer Cells. Journal of Cellular Biochemistry, 113(10): 3143-3152.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Trujillo JA, Sweis RF, Bao R, et al., 2018, T cell-Inflamed Versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Cancer Immunology Research, 6(9): 990-1000.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B27" content-type="article"><label>27</label><element-citation publication-type="journal"><p>Muralidhar S, Filia A, Nsengimana J, et al., 2019, Vitamin D-VDR Signaling Inhibits Wnt/?-Catenin-Mediated Melanoma Progression and Promotes Antitumor Immunity. Cancer Research, 79(23): 5986-5998.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B28" content-type="article"><label>28</label><element-citation publication-type="journal"><p>Luke JJ, Bao R, Sweis RF, et al., 2019, WNT/?-catenin Pathway Activation Correlates with Immune Exclusion Across Human Cancers. Clinical Cancer Research, 25(10): 3074-3083.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B29" content-type="article"><label>29</label><element-citation publication-type="journal"><p>Zhang X, Li P, Bao J, et al., 2005, Suppression of Death Receptor-Mediated Apoptosis by 1, 25-Dihydroxyvitamin D3 Revealed by Microarray Analysis. Journal of Biological Chemistry, 280(42): 35458-35468.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B30" content-type="article"><label>30</label><element-citation publication-type="journal"><p>Mantell D, Owens P, Bundred N, et al., 2000, 1?, 25-Dihydroxyvitamin D3 Inhibits Angiogenesis In Vitro and In Vivo. Circulation Research, 87(3): 214-220.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B31" content-type="article"><label>31</label><element-citation publication-type="journal"><p>Pendas-Franco N, García JM, Pena C, et al., 2008, DICKKOPF-4 is Induced by TCF/?-Catenin and Upregulated in Human Colon Cancer, Promotes Tumour Cell Invasion and Angiogenesis and Is Repressed by 1?, 25-Dihydroxyvitamin D3. Oncogene, 27(32): 4467-4477.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B32" content-type="article"><label>32</label><element-citation publication-type="journal"><p>Maj E, Filip-Psurska B, Milczarek M, et al., 2018, Vitamin D Derivatives Potentiate the Anticancer and Anti-Angiogenic Activity of Tyrosine Kinase Inhibitors in Combination with Cytostatic Drugs in an A549 Non-Small Cell Lung Cancer Model. International Journal of Oncology, 52(2): 337-366.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B33" content-type="article"><label>33</label><element-citation publication-type="journal"><p>Bao B-Y, Yao J, Lee Y-F, 2006, 1?, 25-Dihydroxyvitamin D 3 Suppresses Interleukin-8-Mediated Prostate Cancer Cell Angiogenesis. Carcinogenesis, 27(9): 1883-1893.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B34" content-type="article"><label>34</label><element-citation publication-type="journal"><p>Ben-Shoshan M, Amir S, Dang DT, et al., 2007, 1?, 25-Dihydroxyvitamin D3 (Calcitriol) Inhibits Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway in Human Cancer Cells. Molecular Cancer Therapeutics, 6(4): 1433-1439.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
