PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v7i2.4736ArticleA Proposed Solution to the Interference of IgG Kappa-Type M Protein on LDL-C Detectionhttps://artdesignp.com/journal/PAR/7/2/10.26689/par.v7i2.4736YangChao,YuYang,LiangShuxin,ZhaoHaige,AnNa2023722023-03-29Objective: To explore the interference of monoclonal immunoglobulin (M protein) on the detection of serum LDL-C in patients with multiple myeloma, improve the understanding of this matter, determine and establish the correct method, and provide more accurate clinical results through this case. Methods: A case was selected for analysis by the direct method. Results: The interference of IgG kappa-type M protein on LDL-C detection could not be completely eliminated by the enzymatic method. Conclusion: IgG-type type M protein affects the detection of LDL-C by the enzymatic method; thus, light reagents can be used with the direct method for detection.

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