PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v7i6.5508ArticleDetection and Clinical Significance of Th17/Treg Cell-Related Factors in Patients with Gestational Diabetes Mellitushttps://artdesignp.com/journal/PAR/7/6/10.26689/par.v7i6.5508QinJinjin,WangBei,CaoChenyuan,ZhaoYakun,WangJing,WuHongli2023762023-11-22Objective: To investigate the detection of Th17/Treg cell-related factors in patients with gestational diabetes mellitus (GDM) and its clinical significance. Methods: In this study, a retrospective cohort research method was used to collect the clinical data of 42 patients who were hospitalized in the Affiliated Hospital of Hebei University and received the diagnosis of GDM from January 2018 to December 2022, as well as 42 patients with normal pregnancies during the same period. The Th17/Treg expression levels and metabolism-related indexes in the peripheral blood of patients were detected by radioimmunoassay. Results: The relative expression of Th17 in the serum of patients in the GDM group was significantly higher than that of the control group, and the level of Treg was significantly lower than that of the control group (P < 0.05); the levels of FBG, FINS, 2hBG, TC, TG and HOMA-IR of the patients in the GDM group were significantly higher than that of the control group, and the level of HOMA-β was significantly lower than that of the control group (P < 0.05). Conclusion: The imbalance of the Th17/Treg cell ratio in patients with GDM may be related to their disease progression and prognosis, providing new ideas and strategies for the clinical treatment of GDM.

Yin X, Nie J, Nie X, et al., 2022, The Relationship Between Nuclear Factor-Erythrocyte-Related Factor 2 and Antioxidant Enzymes in the Placenta of Patients with Gestational Diabetes and the Metabolism of Umbilical Cord Endothelial Cells. Cellular and Molecular Biology, 68(12): 97–103.

Reza F, Golnoosh G, Sahar Y, et al., 2022, Circulating Levels of C1q/TNF-Related Protein 3 (CTRP3) and CTRP9 in Gestational Diabetes and Their Association with Insulin Resistance and Inflammatory Cytokines. Laboratory Medicine, 2022.

Li Q, Xu J, Fang H, et al., 2019, Changes of Serum IL-17, IL-1?, IL-10 Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance and Blood Lipids. Shandong Medicine, 59(4): 52–54.

Li D, Chen J, Cao X, et al., 2016, Changes in the Expression of Peripheral Blood Th17/Treg Cells and Related Cytokines in Diabetic Patients. Advances in Modern Biomedicine, 16(30): 5987–5989 + 5960.

Oztop N, Kusku-Kiraz Z, Dervisoglu E, et al., 2016, The Association of Glycemic Markers with Plasma Adipocytokine Levels in Women with Gestational Diabetes. Journal of Diabetes and Metabolism, 7(9): 1000699. https://doi.org/10.4172/2155-6156.1000699

Kuzmicki M, Telejko B, Lipinska D, et al., 2014, The IL-6/IL-6R/sgp130 System and Th17 Associated Cytokines in Patients with Gestational Diabetes. Endokrynologia Polska, 65(3): 169–175.

Li Y, 2014, Study on the Expression Levels of Th1/Th2/Th17/Treg-Related Cytokines in Peripheral Blood of Diabetic Patients, Southern Medical University.

Kuzmicki M, Telejko B, Wawrusiewicz-Kurylonek N, et al., 2013, The Expression of Genes Involved in NF-?B Activation in Peripheral Blood Mononuclear Cells of Patients with Gestational Diabetes. European Journal of Endocrinology, 168(3): 419–427. https://doi.org/10.1530/EJE-12-0654

Song J, Liu N, Peng S, 2012, Detection and Clinical Significance of Th17/Treg Cell-Related Factors in Patients with Gestational Diabetes Mellitus. International Journal of Laboratory Medicine, 33(17): 2069–2070.

Etaati Z, Moazzami Gordarzi R, Kalhori F, et al., 2012, T-Helper Cytokine Patterns and Related Antibodies in Patients with Gestational Diabetes Mellitus. Tehran University Medical Journal, 70(1): 15–20.

He H, 2023, Medical Nutritional Measures for Patients with Gestational Diabetes Mellitus. Renren Health, 2023(15):44.

Zhao Y, 2023, Effects of Health Promotion and Education on Compliance Behavior and Maternal and Infant Outcomes in Patients with Gestational Diabetes Mellitus. Famous Doctors, 2023(8): 189–191.

Shen G, 2023, Nursing Care for Patients with Gestational Diabetes Mellitus Must be Emphasized. Health For All, 2023(5): 22.

Guo S, 2022, Expression of Serum HbA1c and hs-CRP in Patients with Gestational Diabetes Mellitus and Its Relationship with the Occurrence of Neonatal Hypoglycemia. Henan Medical Research, 31(21): 3926–3929.

Liu H, Liu F, 2022, Factors Associated with Abnormal Glucose Metabolism in Patients with Gestational Diabetes Mellitus in Second Pregnancy. Henan Medical Research, 31(18): 3357–3360.