PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v8i1.5906ArticleEffect of TSH Suppression Therapy on Sex Hormone Levels after Thyroid Cancer Surgeryhttps://artdesignp.com/journal/PAR/8/1/10.26689/par.v8i1.5906HeShenglin,SuYa,ZhaoBo,GaoXudong2024812024-01-26Objective: To analyze the effect of thyroid-stimulating hormone (TSH) suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer. Methods: A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data analysis. TSH suppression therapy was implemented during the postoperative period. Patients were grouped according to the TSH level: TSH < 0.1, 0.1 ≤ TSH < 0.5, and TSH ≥ 0.5. Results: Among male patients, there were no significant differences in sex hormone levels at different dosing times and TSH levels (P > 0.05). For female patients, testosterone levels at different dosing times showed no significant differences under the same circumstances (P > 0.05). The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences (P > 0.05). However, the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences (P < 0.05), with the lowest levels observed at 0.1 ≤ TSH < 0.5. Conclusion: The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male patients. However, it has a significant impact on female patients. Therefore, preoperative sex hormone testing is recommended, and postoperative monitoring should include regular sex hormone testing.

Zhu Y, Wang M, Yue Y, et al., 2023, Effect of TSH Suppression Therapy on Thyroid Function in Thyroid Cancer Patients After Radical Surgery. China Health Standard Management, 14(17): 136–139.

Wang X, Zhao F, Yan S, 2022, Effects of Thyrotropin Suppression Therapy on Bone Metabolism, CD44V6 and sIL-2R Levels in Patients with Differentiated Thyroid Cancer. Chinese Journal of Modern Medicine, 32(23): 34–38.

Zhang H, Chang B, 2022, Effect of TSH Suppression Therapy on Thyroid Function and Long-Term Prognosis of Thyroid Cancer Patients After Radical Surgery. Chinese Journal of Drug Abuse Prevention and Treatment, 28(3): 321–325.

Zhao F-L, Kang Y-L, Ma Y-J, et al., 2021, Analysis of the Efficacy of TSH Inhibition Therapy on Elderly Thyroid Cancer Patients After Total Thyroidectomy and Its Effect on Serum Tg, TSH and CEA Levels. Journal of Practical Cancer, 36(12): 1970–1973.

Jin W, Yao X, 2022, Exploring the Efficacy of Thyroid-Stimulating Hormone (TSH) Suppression Therapy in Postoperative Thyroid Cancer Patients. China Medical Digest (Otolaryngology), 37(1): 97–99.

Bai N, Liu C, Zhang X, et al., 2021, Application of TSH Inhibition Therapy in Differentiated Thyroid Cancer Patients After Surgery. Journal of Qiqihar Medical College, 42(24): 2145–2148.

Zuwariya GA, Zhang J, 2023, Retrospective Analysis of Factors Influencing the Achievement of Postoperative TSH Suppression Therapy in Patients with Papillary Thyroid Cancer. China Prescription Drugs, 21(3): 133–135.

Wan Y, 2021, Efficacy of Total Thyroidectomy in the Treatment of Thyroid Cancer and Its Effect on Patients’ Parathyroid Hormone Levels. China Modern Drug Application, 15(19): 65–68.

Li X, Wang Y, Xie J, et al., 2021, Analysis of Factors Influencing Patients’ Adherence to Postoperative Endocrine Therapy for Differentiated Thyroid Cancer. Tumor Prevention and Treatment, 34(9): 856–861.

Zhang Y, Guo Y, 2022, Effects of Bilateral Thyroidectomy for Thyroid Cancer on Postoperative Stress-Related Hormone Levels, Quality of Life and Inflammatory Factors in Patients. Systemic Medicine, 7(7): 128–131.

Zhang D, Zhang C, Sun G, 2021, Effect of Thyroid Lobectomy on Serum-Related Hormone Levels and Prognosis of Thyroid Cancer Patients. Practical Clinical Medicine (Jiangxi), 22(3): 26–28 + 32.

Li J, Zhao Z, 2021, Effects of Total Thyroidectomy and Subtotal Thyroidectomy on Bone Mineral Density and TSH, TgAb Levels in Patients with Differentiated Thyroid Cancer. Clinical Research, 29(3): 16–18.

Tian R, Wang M, 2022, Effect of Thyrotropin Receptor Antibodies on Long-Term Suppression of Thyrotropin Levels in Graves’ Disease Patients After Treatment. Jiangsu Medicine, 48(9): 931–934 + 938.

Zhang D, 2022, Effect of Total Thyroidectomy in the Treatment of Bilateral Nodular Goiter and Its Effect on Postoperative Serum TSH, TgAb and TPO-Ab. Sichuan Journal of Physiological Sciences, 44(12): 2089–2092.

Wang M, Zhao S, Chen Y, et al., 2022, Effect of TSH Inhibition Combined with Radioactive 131? in the Treatment of PTC in Women of Reproductive Age. Journal of Guangxi Medical University, 2022(8): 1297–1302.