<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Proceedings of Anticancer Research</journal-title></journal-title-group><issn>2208-3545</issn><eissn>2208-3553</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/par.v8i3.7207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Clinical Application and Prospect of New Radiotherapy Technology in Cancer Treatment</title><url>https://artdesignp.com/journal/PAR/8/3/10.26689/par.v8i3.7207</url><author>DaiKimi</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>8</volume><issue>3</issue><history><date date-type="pub"><published-time>2024-06-19</published-time></date></history><abstract>Objective: Carbon ion therapy, a new radiotherapy technology, has shown its remarkable efficacy and potential in cancer treatment, especially in the treatment of refractory tumors. Methods: This paper clarifies the physical basis, technological change, and clinical practice effect of carbon ion therapy, comprehensively discusses the future prospects, and evaluates the clinical application effect. Results: The technology has significantly improved the treatment effectiveness and received a positive response from patients. Conclusion: Carbon ion therapy technology has become a major innovation in the field of cancer treatment. It not only has a profound impact on many current cancer therapy methods but also indicates the application blueprint for a wider range of cancer types in the future, showing a new chapter of medical technology advancement.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Amaldi U, Kraft G, 2005, Radiotherapy with Beams of Carbon Ions. Reports on Progress in Physics, 68(8): 1861–1882.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Mohamad O, Sishc B, Saha J, et al., 2017, Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair. Cancers, 9(12): 66.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Takahashi A, Yano T, Matsumoto H, et al., 1998, Effects of Accelerated Carbon-Ions on Growth Inhibition of Transplantable Human Esophageal Cancer in Nude Mice. Cancer Letters, 122(1–2): 181–186.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Burigo LN, Ramos-Méndez J, Bangert M, et al., 2019, Simultaneous Optimization of RBE-Weighted Dose and Nanometric Ionization Distributions in Treatment Planning with Carbon Ions. Physics in Medicine &amp; Biology, 64(1): 015015.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Lazar AA, Schulte R, Faddegon B, et al., 2018, Clinical Trials Involving Carbon?Ion Radiation Therapy and the Path Forward. Cancer, 124(23): 4467–4476.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Orlandi E, Barcellini A, Vischioni B, et al., 2023, The Role of Carbon Ion Therapy in the Changing Oncology Landscape—A Narrative Review of the Literature and the Decade of Carbon Ion Experience at the Italian National Center for Oncological Hadrontherapy. Cancers, 15(20): 5068.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Malouff TD, Mahajan A, Krishnan S, et al., 2020, Carbon Ion Therapy: A Modern Review of an Emerging Technology. Frontiers in Oncology, 10(4): 82</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Shiba S, Okamoto M, Kiyohara H, et al., 2021, Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma. Cancers, 13(5): 1099.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Liermann J, Naumann P, Weykamp F, et al., 2021, Effectiveness of Carbon Ion Radiation in Locally Advanced Pancreatic Cancer. Frontiers in Oncology, (11): 708884.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Malouff TD, Peterson JL, Mahajan A, et al., 2019, Carbon Ion Radiotherapy in the Treatment of Gliomas: A Review. Journal of Neuro-Oncology, 145(2): 191–199.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Yasuda S, Kato H, Imada H, et al., 2020, Long-Term Results of High-Dose 2-Fraction Carbon Ion Radiation Therapy for Hepatocellular Carcinoma. Advances in Radiation Oncology, 5(2): 196–203.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Held T, Windisch P, Akbaba S, et al., 2019, OC-009 Carbon-Ion Reirradiation for Recurrent Head and Neck Cancer: A Single-Institutional Experience. Radiotherapy and Oncology, 132(5): 803–811.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Gunma University Heavy Ion Medical Center, 2019, Heavy Ion Radiation Therapy, viewed January 19, 2024, http://www.rb-meirong.com/zhonglizi/</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Okano N, Sakai M, Shibuya K, et al., 2021, Safety Verification of Carbon-Ion Radiotherapy for Patients with Cardiac Implantable Electronic Devices (CIEDs). Journal of Radiation Research, 63(1): 122–127.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Akbaba S, Held T, Lang K, et al., 2019, Bimodal Radiotherapy with Active Raster-Scanning Carbon Ion Radiotherapy and Intensity-Modulated Radiotherapy in High-Risk Nasopharyngeal Carcinoma Results in Excellent Local Control. Cancers, 11(3): 379.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Okazaki S, Ohno T, Takura T, et al., 2024, Cost-Effectiveness Comparison of Carbon-Ion Radiation Therapy and Transarterial Chemoembolization for Hepatocellular Carcinoma. Advances in Radiation Oncology, 9(4): 101441.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Mohamad O, Tabuchi T, Nitta Y, et al., 2019, Risk of Subsequent Primary Cancers After Carbon ion Radiotherapy, Photon Radiotherapy, or Surgery for Localised Prostate Cancer: A Propensity Score-Weighted, Retrospective, Cohort Study. The Lancet Oncology, 20(5): 674–685.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Bazanov AM, Butenko AV, Govorov AI, et al., 2020, Laser Ion Source in Injection Facility of NICA Project. Physica Scripta, 95(5): 055307.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Zhou H, Tu C, Yang P, et al., 2022, Carbon Ion Radiotherapy Triggers Immunogenic Cell Death and Sensitizes Melanoma to Anti-PD-1 Therapy in Mice. OncoImmunology, 11(1): 2057892.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Konings K, Belmans N, Vermeesen R, et al., 2019, Targeting the Hedgehog Pathway in Combination with X?Ray or Carbon Ion Radiation Decreases Migration of MCF?7 Breast Cancer Cells. International Journal of Oncology, 55(6): 1339–1348.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
