<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Proceedings of Anticancer Research</journal-title></journal-title-group><issn>2208-3545</issn><eissn>2208-3553</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/par.v8i5.8297</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Primary Malignant Melanoma of the Larynx: Case Report and Literature Review</title><url>https://artdesignp.com/journal/PAR/8/5/10.26689/par.v8i5.8297</url><author>WangPan,WuYashan,ZhangPei,WangYanan</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>8</volume><issue>5</issue><history><date date-type="pub"><published-time>2024-09-25</published-time></date></history><abstract>Primary malignant melanoma of the larynx is extremely rare. This paper reports a case of a patient with primary malignant melanoma of the larynx. Preoperative laryngoscopy revealed a cauliflower-like mass in the supraglottic region, and a CT scan of the pharynx suggested laryngeal cancer with cervical lymph node metastasis. The patient underwent a total laryngectomy with lymph node dissection, and postoperative pathology confirmed a malignant melanoma in the supraglottic region of the larynx.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Chinese Society of Pathology, Dermatopathology Group of the Chinese Society of Pathology, 2021, Clinical Practice Guidelines for Pathological Diagnosis of Melanoma (2021 Edition). Chinese Journal of Pathology, 50(6): 572–582.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Terada T, Saeki N, Toh K, et al., 2007, Primary Malignant Melanoma of the Larynx: A Case Report and Literature Review. Auris Nasus Larynx, 34(1): 105–110. https://doi.org/10.1016/j.anl.2006.09.027</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Wang Y, Yang C, Huo X, 2020, Report of a Case of Primary Glottic Malignant Melanoma of the Larynx. Jilin Medical Journal, 41(7): 1782–1783.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Wang X, Long J, 2017, Research Progress on the Pathogenesis of Melanoma. Chinese Journal of Plastic Surgery, 33(5): 397–400.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Ascierto PA, Kirkwood JM, Grob JJ, et al., 2012, The Role of BRAF V600 Mutation in Melanoma. J Transl Med, 10: 85. https://doi.org/10.1186/1479-5876-10-85</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Bai X, Kong Y, Chi Z, et al., 2017, MAPK Pathway and TERT Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases. Clin Cancer Res, 23(20): 6120–6127. https://doi.org/10.1158/1078-0432.CCR-17-0980</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Newell F, Kong Y, Wilmott JS, et al., 2019, Whole-Genome Landscape of Mucosal Melanoma Reveals Diverse Drivers and Therapeutic Targets. Nat Commun, 10(1): 3163. https://doi.org/10.1038/s41467-019-11107-x</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Hayward NK, Wilmott JS, Waddell N, et al., 2017, Whole-Genome Landscapes of Major Melanoma Subtypes. Nature, 545(7653): 175–180. https://doi.org/10.1038/nature22071</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Shoushtari AN, Bao R, Luke JJ, 2020, PD-1 Blockade in Chinese versus Western Patients with Melanoma. Clin Cancer Res, 26(16): 4171–4173. https://doi.org/10.1158/1078-0432.CCR-20-1558</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Cojocaru O, Aschie M, Mocanu L, et al., 2015, Laryngeal Primary Malignant Melanoma: A Case Report. Rom J Morphol Embryol, 56(4): 1513–1516.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Reuter VE, Woodruff JM, 1986, Melanoma of the Larynx. Laryngoscope, 96(4): 389–393. https://doi.org/10.1288/00005537-198604000-00010</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Rozeman EA, Hoefsmit EP, Reijers ILM, et al., 2021, Survival and Biomarker Analyses from the OpACIN-neo and OpACIN Neoadjuvant Immunotherapy Trials in Stage III Melanoma. Nat Med, 27(2): 256–263. https://doi.org/10.1038/s41591-020-01211-7</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
