PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v9i2.9965ArticleThe Spatial Location of Chromosomes in Dividing Cells and the Relative Stability of Chromosome Spatial Structurehttps://artdesignp.com/journal/PAR/9/2/10.26689/par.v9i2.9965WuChunxiao,JiangDongyun,JiangTao,XuLuxia,XuQian,ZhaoMeng,ZhuQin,GuoZhigang,PanJinlan,ChenSuning2025922025-04-02The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions. We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior. In this study, we explored the relative spatial positional relationships of chromosomes [t(9;22) and t(15;17)] in B-ALL cells by using the three-dimensional DNA fluorescent in situ hybridization (3D-FISH) method. The results showed that chromosomes [t(9;22) and t(15;17)] showed relatively stable spatial relationships. The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease.

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