PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v9i4.11506ArticleResearch Progress on the Mechanism of Action of Huangqin (Scutellaria baicalensis) in the Treatment of Lung Cancerhttps://artdesignp.com/journal/PAR/9/4/10.26689/par.v9i4.11506ZhouChaowang,ZhangLei,XieMengzhou,HeZuomei2025942025-08-06This article summarizes recent domestic literature on the use of Huangqin (Scutellaria baicalensis) in the treatment of lung cancer. It reviews the mechanism of action of Huangqin in treating lung cancer from six aspects: inhibiting the growth of lung cancer cells, inducing apoptosis of lung cancer cells, inducing autophagy of lung cancer cells, inhibiting the migration of lung cancer cells, promoting the differentiation of lung cancer cells, and improving immune function. The aim is to provide a reference for the material basis and further research on the anti-inflammatory and anti-tumor efficacy of Huangqin.

Liu H, Yang J, Wang L, et al., 2025, Luteolin Inhibits Glioblastoma by Regulating ROS Levels Through the NFE2L2/x-CT/GPX4 Signaling Axis. Tianjin Medical Journal, 1–6.

Wang S, Liu Y, Yu H, et al., 2025, Bidirectional Regulation of Reactive Oxygen Species by Zeolite-Based Imidazolium Salt Framework 8 Nanomaterials: From Tumor Therapy, Antibacterial to Cell Protection. Chinese Journal of Tissue Engineering Research, 1–11.

Meng X, Li M, Gu H, et al., 2025, Optimization of Zengshengping Prescription for the Treatment of Lung Cancer and Its Immunomodulatory Mechanism Based on the Theory of “Lung and Large Intestine Being Internally and Externally Related”. Chinese Traditional Patent Medicine, 47(5): 1666–1671.

Xiao J, He J, Zeng X, et al., 2025, Study on the Causal Relationship Between Circadian Rhythm Disorder and the Risk of Lung Cancer Occurrence and the Prediction of Interventional Chinese Medicine. Chinese General Practice, 1–15.

Yang R, Liu Y, Wang L, et al., 2025, Exploring the Effective Components and Mechanism of Scutellaria baicalensis in the Treatment of Lung Cancer Based on Network Pharmacology. Medical Information, 38(7): 18–24.

Bao Y, 2024, BIBR1532 Enhances the Radiosensitivity and Radiation-Induced Antitumor Immunity of Non-Small Cell Lung Cancer, thesis, University of Science and Technology of China.

Guo L, 2024, Study on the Synergistic Inhibitory Effect of Isoflavones and GLUT1 Inhibitor BAY-876 on Colorectal Cancer, thesis, Hebei Normal University.

Sun X, 2023, Exploring the Toxic Effects of Arsenic Trioxide and the Protective Effects of Baicalin Based on Meta-Analysis and Experimental Verification, thesis, Hebei University of Chinese Medicine.

He G, 2021, Study on the Mechanism of Iodine-125 Particles Combined with Wild Baicalin in the Treatment of Lung Cancer, thesis, Shandong University.

Sun G, 2023, Study on the Mechanism of Scutellaria baicalensis Improving Skin Aging in Mice Through REV-ERBα/BMAL1, thesis, Jinan University.

Xu J, Chen Y, Zou X, 2018, Preventive Effect of Huangqin Oil Paste on Skin Toxicity Reactions Related to Molecular Targeted Therapy for Lung Cancer. Chinese and Foreign Medical Research, 16(2): 3–5.

Li C, 2024, Molecular Mechanism Study of Scutellaria baicalensis in the Treatment of Non-Small Cell Lung Cancer Based on Network Pharmacology. Frontiers in Medicine, 14(9): 31–35.

Wu K, Chen S, Jiang C, et al., 2025, Exploring the Mechanism of Wogonin in the Treatment of Non-Small Cell Lung Cancer Based on Network Pharmacology, Molecular Docking, and Experimental Verification. Traditional Chinese Drug Research and Clinical Pharmacology, 36(3): 416–424.

Liu H, Wang C, Fan L, 2024, Study on the Effect and Mechanism of Huangjing Combined with Huangqin on the Proliferation and Apoptosis of Lung Cancer Cells. World Chinese Medicine, 19(21): 3289–3295.

Zheng X, Li D, Liu P, 2025, Research Progress on the Anti-Tumor Effects of Traditional Chinese Medicine Through Regulating the AMPK/mTOR Signaling Pathway. Chinese Journal of Experimental Traditional Medical Formulas, 1–15.

Hou G, Li M, Zhao P, et al., 2019, In Vitro Antitumor Effect of Keerkang Granules on Lung Adenocarcinoma Cell Line A549. Herald of Medicine, 38(1): 27–32.

Huang J, Lin S, Jiang C, et al., 2025, Research Progress on the Antitumor Effect of Traditional Chinese Medicine by Intervening in the Nrf2/GPX4 Signaling Pathway. China Pharmacy, 36(4): 507–512.

Peng X, Ma Z, Du Q, et al., 2012, One Case of Lung Cancer Treated with Targeted Drugs Combined with Chinese Medicine. Chinese Medicine and Pharmacology, 2(21): 159–160.

Wang S, Dong L, Liu H, et al., 2016, Effect of Wogonin on the Proliferative Activity of Human Lung Cancer A549 Cell Line. Heilongjiang Medicine, 29(1): 25–27.

Jin Z, Wu W, Fang P, et al., 2024, Exploring the Mechanism of Scutellaria baicalensis, Atractylodes macrocephala, and Poria cocos in the Treatment of Diabetes Based on Network Pharmacology and Molecular Docking. Clinical Research of Traditional Chinese Medicine, 16(30): 1–9.

Hu Y, Gao L, Hao W, et al., 2023, Study on the Mechanism of “Huangqi-Banxia” Drug Pair in the Treatment of Non-Small Cell Lung Cancer. Modern Traditional Chinese Medicine, 43(3): 106–117.

Yang J, Zhu X, Yuan P, et al., 2022, Exploring the Material Basis and Molecular Mechanism of Polygonatum sibiricum in the Treatment of Non-Small Cell Lung Cancer Based on Network Pharmacology and Molecular Docking. China Medical Herald, 19(8): 16–20.

Zhang X, Li L, Kang L, et al., 2022, Jiang Liangxie’s Experience in Treating Post-Lung Cancer Surgery Cough by Cleverly Using Corner Medicine to Regulate the Three Jiao. Global Traditional Chinese Medicine, 15(12): 2432–2435.

Liu X, Zhang Y, Gu L, et al., 2015, Study on the Anti-Influenza Virus Effect of Baicalin in Vitro. Tianjin Journal of Traditional Chinese Medicine, 32(4): 229–233.

Lei W, Li J, Shui X, 2015, Study on the Effect of Baicalin on the Proliferation and Migration of Lung Cancer Cell A549. Genomics and Applied Biology, 34(8): 1612–1616.

Shi Y, Jia D, Gao M, et al., 2022, Research Status on the Anti-Tumor Effect and Mechanism of Baicalein. Chinese Journal of Clinical Pharmacology, 38(14): 1692–1695.

Wang W, Jin C, Fan F, et al., 2021, Effects of Fuzheng Jiedu Decoction Combined with Gemcitabine and Cisplatin on T Cell Subsets and Serum Tumor Markers in Patients with Advanced Non-Small Cell Lung Cancer. Progress in Modern Biomedicine, 21(4): 710–713.

Wang Y, Tian J, Luo B, et al., 2024, Research Progress on the Prevention and Treatment of Lung Cancer Metastasis by Regulating Natural Killer Cells with Traditional Chinese Medicine. Shanghai Journal of Traditional Chinese Medicine, 58(12): 170–178.

Wang H, Sun X, Zhang R, 2023, Exploring the Effect of Shengyang Yiwei Decoction on the Immunity of Lung Cancer Rats Based on the PI3K/Akt/NF-κB Signaling Pathway. Tianjin Medical Journal, 51(7): 739–745.