PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/par.v9i6.12909ArticleAssociation between Glutathione S-transferase Gene Polymorphisms and Lung Squamous Cell Carcinoma in Patients with Chronic Obstructive Pulmonary Disease: A Case-control Studyhttps://artdesignp.com/journal/PAR/9/6/10.26689/par.v9i6.12909ZhaoMengdan,HaoJiqing2025962025-12-08This case-control study evaluated the frequency of Glutathione S-transferase Mu 1 (GSTM1) deletion and Glutathione S-transferase Alpha 1 (GSTA1) mutation in chronic obstructive pulmonary disease (COPD) patients, whether they had concomitant lung squamous cell carcinoma (LSCC) or not, to assess their connection with cancer susceptibility. By means of multivariate logistic regression analysis, the GSTM1 null genotype serves as a significant standalone risk factor for LSCC, in addition to variables like age, smoking history, emphysema, body mass index (BMI), albumin level, and neutrophil-to-lymphocyte ratio (NLR). A predictive model incorporating these factors demonstrated superior discriminative ability compared to the established COPD Lung Cancer Screening Score (COPD-LUCSS).

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