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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">SSR</journal-id><journal-title-group><journal-title>Scientific and Social Research</journal-title></journal-title-group><issn>2661-4332</issn><eissn>2981-9946</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/ssr.v7i5.10725</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Data from China: Analysis of Research Hotspots in the Field of Digital Therapeutics in the Chinese Context (1989–2021)</title><url>https://artdesignp.com/journal/SSR/7/5/10.26689/ssr.v7i5.10725</url><author>BaiJike,LucOriana,LiaoShaobing,QiQige,JinJing,LiuXuan</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>7</volume><issue>5</issue><history><date date-type="pub"><published-time>2025-06-06</published-time></date></history><abstract>Objective‌: China is globally leading in digitalization. However, due to language barriers, there are few international studies on digital medicine based on the Chinese context. This paper focuses on Chinese data to explore the distribution and characteristics of research hotspots in the field of digital therapy in China. Methods‌: By quantifying the published literature on digital therapy from 1989 to 2021 in the authoritative Chinese database CNKI, keyword maps were drawn to sort out specific research directions and hotspot distributions in the field of digital therapy in China, and to predict future research trends and challenges. The literature was retrieved from the CNKI database, exported, and converted into CiteSpace 5.7.R2 software for solving six quantitative indicators, clustering, and map drawing. Under the guidance and constraints of the results, the development context, research directions, core keywords, and hotspots in the field of digital therapy were analyzed. Results‌: A total of 458 articles were included. The clustering was credible (Q = 0.8379&amp;gt;0.3; mean S = 0.9447&amp;gt;0.6), and 19 significant research directions were obtained (S&amp;gt;0.6). Four high-frequency core keywords (F&amp;gt;33) and eight high-centrality core keywords (C&amp;gt;28) were identified; there were no prominent nodes. Conclusion‌: In the field of digital therapy represented by Chinese literature, there are four mainstream research directions: exploration of digital medical theoretical concepts, multi-field integration of digital medical extensions, digital applications in specific disease scenarios, and infrastructure and policy support. However, from the perspective of literature centrality and mutation indicators, a solid theoretical core and landmark technological breakthroughs have not yet been formed, highlighting the huge potential and challenges of future research and application in this field in the Chinese context.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Zeng Q, Gao XY, Bai SZ, 2022, Theory and Practice of Smart Health Management. Chinese Journal of Health Management, 16(1): 3–6.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Miao BY, Arneson D, Wang M, et al., 2022, Open Challenges in Developing Digital Therapeutics in the United States. PLOS Digit Health, 1(1): e0000008. https://doi.org/10.1371/journal.pdig.0000008</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Hong JS, Wasden C, Han DH, 2021, Introduction of Digital Therapeutics. Computer Methods and Programs in Biomedicine, 2021(209): 106319.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Li RXG, Zhao X, 2023, Application of Digital Therapeutics in Asthma Management. Chinese Journal of Respiratory Diseases, 11(3): 344–348.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Wang C, Lee C, Shin H, 2023, Digital Therapeutics from Bench to Bedside. NPJ Digital Medicine, 6(1): 38. https://doi.org/10.1038/s41746-023-00777-z</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Furstenau D, Gersch M, Schreiter S, 2023, Digital Therapeutics: Apps on Prescription. Business &amp; Information Systems Engineering, 65(3): 349–360. https://doi.org/10.1007/s12599-023-00804-z</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Miao BY, Arneson D, Wang M, et al., 2022, Open Challenges in Developing Digital Therapeutics in the United States. PLOS Digital Health, 1(9): e0000027. https://doi.org/10.1371/journal.pdig.0000027</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Refolo P, Sacchini D, Spagnolo AG, 2022, Ethics of Digital Therapeutics (DTx). European Review for Medical and Pharmacological Sciences, 26(9): 3221–3230. https://doi.org/10.26355/eurrev_202209_29741</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Chinese Association of Drug Abuse Prevention and Treatment, 2023, Expert Consensus on Digital Therapeutics for Addictive Disorders. Zhonghua Medical Journal, 103(35): 2757–2764.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>He JY, Zhao LM, Liu K, 2023, Assessment of Digital Therapeutics for Self-management in Chinese Hypertensive Patients. Chinese Medical Journal, 136(5), 387–392.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Sun C, Fan J, 2022, Application of Digital Therapeutics in the Treatment of Nonalcoholic Fatty Liver Disease. Clinical Hepatology, 5(2): 123–129.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Zeng Q, Gao XY, Bai SZ, 2022, The Theory and Practice of Intelligent Health Management. Chinese Journal of Health Management, 16(1): 1–8.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Chen CM, 2006, CiteSpace II: Detecting and Visualizing Emerging Trends and Transient Patterns in Scientific Literature. JASIST, 57(3): 359–377.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Chen CM, Chen Y, Horowitz M, 2009, Towards an Explanatory and Computational Theory of Scientific Discovery. Journal of Informetrics, 3(3): 191–209.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Chen CM, Song IY, Yuan XJ, 2008, The Thematic and Citation Landscape of Data and Knowledge Engineering (1985–2007). Data &amp; Knowledge Engineering, 6(7): 234–259.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Song YH, Yang SL, 2014, Research Progress in Library Science, Information Science and Archival Science from an International Perspective: Information Visualization Analysis Based on CiteSpace. Library Forum, 6(3): 1–13.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Fang Y, 2015, Visualizing the Structure and the Evolving of Digital Medicine: A Scientometrics Review. Scientometrics, 105(1): 5–21.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Jaccard P, 1901, Etude Comparative de la Distribution Florale dans Une Portion des Alpes et des Jura. Bulletin del la Societe Vaudoise des Sciences Naturelles, 37(5): 547–579.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Newman MEJ, 2006, Modularity and Community Structure in Networks. PNAS, 103(23): 8577–8582.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Salton G, Yang CS, Wong AA, 1975, Vector Space Model for Information Retrieval. Communications of the ACM, 18(11): 613–620.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>Dunning T, 1993, Accurate Methods for the Statistics of Surprise and Coincidence. Computational Linguistics, 19(1): 61–74.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Osareh F, 1996, Bibliometrics, Citation Analysis and Co-Citation Analysis: A Review of Literature. Libri, 46(3): 10–21.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>Zhao RY, Wang M, 2011, Visual Analysis of Traditional Chinese Medicine Research from an International Perspective. Journal of Medical Informatics, 2011, 7(2): 36–41.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Song YH, Yang SL, 2014, Research Progress in Library Science, Information Science and Archival Science from an International Perspective: Information Visualization Analysis Based on CiteSpace. Library Forum, 6(3): 1–13.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Fang Y, 2015, Visualizing the Structure and the Evolving of Digital Medicine: A Scientometrics Review. Scientometrics, 105(1): 5–21.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Guo Q, 2011, Intelligent Health Management. Health Research, 31(2): 81–85.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B27" content-type="article"><label>27</label><element-citation publication-type="journal"><p>Xu PH, Zong WH, Zhou Z, et al., 2015, Investigation and Analysis of the Current Status of Digital Medical Construction in Public Hospitals in my Country. Journal of Chinese Health Information Management, 2015(2): 124–130.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B28" content-type="article"><label>28</label><element-citation publication-type="journal"><p>Chen JX, 2014, Preface to “Moving towards Digital Medical Care — Reconstructing the Theoretical System of Digital Hospitals”. China Information Industry (e-Medical), 2014(7): 64.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
