URUrology Research3083-49102981-8230Bio-Byword Scientific Publishing Pty. Ltd.10.26689/ur.v3i3.12411ArticleThe Roles of E2F5 in Tumor Cell Cycle: The Gatekeeper or Destroyer?https://artdesignp.com/journal/UR/3/3/10.26689/ur.v3i3.12411DuYingwen,WangDanyun,LiangAidi,TangXinru,ChenJiansen,YaoRuizhi,MengLei,XieJianxing,ChenMing,XiangSongtao,LinCanbin2025332025-10-21E2F5 is a member of E2F transcription factor superfamily, controlling many molecular activities, such as cell proliferation, cell differentiation, DNA repair and cell death. Therefore, it is closely related to the occurrence, development and prognosis of a variety of cancers. In recent years, with the rapid development of bioinformatics, genomics and epigenetics, this study has further elucidated of E2F5 in the tumor cell cycle. Based on the latest research reports, this study reviewed the structural composition, dynamic activity regulation of E2F5, and how its transcription program driven by carcinogenic activity changed the progress of various tumor cell cycles, especially how it converted from a “gatekeeper” to a “destroyer”, thus affecting abnormal biological behaviors of tumor cells. Our aim is to provide a new direction for the development of E2F5 targeted therapy strategies and drug resistance in the future.

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